Lynch syndrome: five unanswered questions

Lynch syndrome: five unanswered questions

Despite the great advances that have occurred in the century following the first description of a Lynch syndrome (LS) family and more especially, in more than 20 years since the discovery of causal mutations in the mismatch repair genes (MMR), long-standing clinical questions remain unanswered. Moreover, as a result of novel technologies, new questions have arisen. With this commentary, we aim ...

Unanswered questions in childhood idiopathic nephrotic syndrome

Editorial Implication for health policy/practice/research/medical education: Recent advances in molecular genetics have helped in unraveling the genetic component of idiopathic nephrotic syndrome in children. Similar advances in understanding the environmental triggers and immune defects will help better understand the pathogenesis of the disease. It is hoped that the above advancements will ul...

E-Learning: some unanswered questions

Yoga: Some Unanswered Questions

Grover et al (1994) have provided an excellent and thought provoking analysis of the usefulness of yoga in treating neurotic disorders. Some questions however remain. One criticism of psychotherapy is that the criteria for the selection of suitable candidates usually identify patients with good prognostic features-patients who may improve even without any therapeutic intervention. Another criti...

Pregnancy- Some Unanswered Questions

The definition of pregnancy as the state of a female in the time interval between fertilization of her ova and the expulsion of the foetuses at term, lays focus on the maternal organism and casual thinking tends to emphasize maternal physiology and welfare. In part, this is due to the fact that the maternal organism is reasonably accessible for day to day observations and measurements which do ...